Studies to date show that most inherited cases of breast cancer have been associated with two genes: BRCA1, which stands for BReast CAncer gene one, and BRCA2, or BReast CAncer gene two. These genes function to keep breast cells growing normally and to prevent any cancer cell growth. However, if these genes are abnormal or mutate, they are associated with an increased breast cancer risk. Studies have shown that bnormal BRCA1 and BRCA2 genes may account for up to 10% of all breast cancers.
Women diagnosed with breast cancer who have an abnormal BRCA1 or BRCA2 gene often have a family history of breast cancer, ovarian cancer, or both. But it’s also important to remember that most women with breast cancer have no family history of the disease.
Identifying BRCA1 and BRCA2 has led to new techniques for lowering, detecting, and treating breast cancer, and lowering the risk for the disease. For women who wish to be tested, we can now establish whether the two genes are normal or not.
But there’s still a lot more to learn about these genes. And other genes probably also play a role in the development of breast cancer, for women both with and without a family history of the disease.
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